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Systemic Anti-Cancer Therapy Regimen Library

Home > GYN CX Locally advanced - cARBOplatin and PACLItaxel [Q1W] induction followed by cISplatin [Q1W] chemoradiation [INTERLACE] > GYN - cARBOplatin AUC2 and PACLItaxel 80 mg/m2 [Q1W] induction
This regimen is a component of GYN CX Locally advanced - cARBOplatin and PACLItaxel [Q1W] induction followed by cISplatin [Q1W] chemoradiation [INTERLACE]

Part 1: cARBOplatin and PACLItaxel [Q1W] induction (GYN CX Locally advanced - cARBOplatin and PACLItaxel [Q1W] induction followed by cISplatin [Q1W] chemoradiation [INTERLACE] )

Treatment Overview

Cycles 1 to 3 - 7 days - including hypersensitivity pre-medications

Cycle length:
7

paclitaxel: Tapering schedule of pre-medications is for patients who did not experience a hypersensitivity reaction to the previous dose of weekly paclitaxel.

Cycles 4 to 6 - 7 days - no hypersensitivity pre-medications

Cycle length:
7

paclitaxel: Tapering schedule of pre-medications is for patients who did not experience a hypersensitivity reaction to the previous dose of weekly paclitaxel.

Cycle details

Cycles 1 to 3 - 7 days - including hypersensitivity pre-medications

Medication Dose Route Days Max Duration
dexamethasone * 8 mg oral administration 1, 2, 3
ondansetron 8 mg oral administration 1
loratadine * 10 mg oral administration 1
PACLItaxel * 80 mg/m² intravenous 1 60 minutes
cARBOplatin * 2 AUC (area under the curve) intravenous 1 60 minutes
ondansetron 8 mg oral administration 1
domperidone 10 mg Three times daily oral administration 1

paclitaxel: Tapering schedule of pre-medications is for patients who did not experience a hypersensitivity reaction to the previous dose of weekly paclitaxel.

Cycles 4 to 6 - 7 days - no hypersensitivity pre-medications

Medication Dose Route Days Max Duration
dexamethasone * 8 mg oral administration 1, 2, 3
ondansetron 8 mg oral administration 1
PACLItaxel * 80 mg/m² intravenous 1 60 minutes
cARBOplatin * 2 AUC (area under the curve) intravenous 1 60 minutes
ondansetron 8 mg oral administration 1
domperidone 10 mg Three times daily oral administration 1

paclitaxel: Tapering schedule of pre-medications is for patients who did not experience a hypersensitivity reaction to the previous dose of weekly paclitaxel.

Full details

Cycles 1 to 3 - 7 days - including hypersensitivity pre-medications

Day: 1

Medication Dose Route Max duration Details
dexamethasone * 8 mg oral administration
Instructions:

ONE hour prior to chemotherapy with food.
ondansetron 8 mg oral administration
Instructions:

ONE hour prior to chemotherapy.
loratadine * 10 mg oral administration
Instructions:

ONE hour prior to paclitaxel infusion.
    PACLItaxel * 80 mg/m² intravenous 60 minutes
    Instructions:
    • Prepare solution in PVC-free bag and administer via polyethylene lined administration set with an in-line filter of 0.22 microns or less in size.
    • Please carry out graded challenge as per institutional policy.
    cARBOplatin * 2 AUC (area under the curve) intravenous 60 minutes
    Instructions:

    Hypersensitivity risk increases with number of cycles of carboplatin.
    ondansetron 8 mg oral administration
    Instructions:

    EIGHT hours after chemotherapy OR before bed.
    domperidone 10 mg Three times daily oral administration
    Instructions:

    When required for nausea and/or vomiting.

    • The choice of rescue antiemetic may be substituted to reflect institutional policy or individual patient characteristics.

    Day: 2

    Medication Dose Route Max duration Details
    dexamethasone * 8 mg oral administration
    Instructions:

    ONCE daily in the morning with food.

    • This dose may be reduced or omitted at clinician’s discretion.

    Day: 3

    Medication Dose Route Max duration Details
    dexamethasone * 8 mg oral administration
    Instructions:

    ONCE daily in the morning with food.

    • This dose may be reduced or omitted at clinician’s discretion.

    Cycles 4 to 6 - 7 days - no hypersensitivity pre-medications

    Day: 1

    Medication Dose Route Max duration Details
    dexamethasone * 8 mg oral administration
    Instructions:

    ONE hour prior to chemotherapy with food.
    ondansetron 8 mg oral administration
    Instructions:

    ONE hour prior to chemotherapy.
    PACLItaxel * 80 mg/m² intravenous 60 minutes
    Instructions:
    • Prepare solution in PVC-free bag and administer via polyethylene lined administration set with an in-line filter of 0.22 microns or less in size.
    • Please carry out graded challenge as per institutional policy.
    cARBOplatin * 2 AUC (area under the curve) intravenous 60 minutes
    Instructions:

    Hypersensitivity risk increases with number of cycles of carboplatin.
    ondansetron 8 mg oral administration
    Instructions:

    EIGHT hours after chemotherapy OR before bed.
    domperidone 10 mg Three times daily oral administration
    Instructions:

    When required for nausea and/or vomiting.

    • The choice of rescue antiemetic may be substituted to reflect institutional policy or individual patient characteristics.

    Day: 2

    Medication Dose Route Max duration Details
    dexamethasone * 8 mg oral administration
    Instructions:

    ONCE daily in the morning with food.

    • This dose may be reduced or omitted at clinician’s discretion.

    Day: 3

    Medication Dose Route Max duration Details
    dexamethasone * 8 mg oral administration
    Instructions:

    ONCE daily in the morning with food.

    • This dose may be reduced or omitted at clinician’s discretion.

    Supportive Care Factors

    Factor Value
    Emetogenicity: Medium
    Hypersensitivity / Infusion related reaction risk: High - routine premedication recommended

    References

    Novartis New Zealand Ltd. Paclitaxel Ebewe New Zealand Data Sheet 27 November 2023. https://www.medsafe.govt.nz/profs/Datasheet/p/PaclitaxelEbeweinj.pdf (Accessed 9 July 2025).

    Boulanger J, Boursiquot JN, Cournoyer G, et al. Management of hypersensitivity to platinum- and taxane-based chemotherapy: cepo review and clinical recommendations. Curr Oncol. 2014;21(4):e630-e641., PMID: 25089112

    Castells, M.C., Matulonis, U.A., and Horton, TM. Infusion reactions to systemic chemotherapy. Savarese DMF and Feldweg AM, ed. UpToDate. Waltham, MA: UpToDate Inc. https://www.uptodate.com/contents/infusion-reactions-to-systemic-chemotherapy (Accessed 26 March 2021).

    * The medicines, doses, combinations, and schedule in this treatment regimen have been carefully reviewed against international best practice guidelines by specialists in medical oncology around New Zealand and this advice has been accepted for publication by Te Aho o Te Kahu (the Cancer Control Agency). Sometimes medicines that are used in routine clinical practice have not been through a formal review process by the NZ Medicines Regulator Medsafe and are therefore considered unapproved or off-label. These medicines are legally able to be prescribed through sections 25 and 29 of the Medicines Act and by obtaining informed consent from patients. All treatment regimens listed on this website have been through robust peer review and are considered an accepted standard of care, whether prescribed through sections 25 or 29 or carrying formal Medsafe Approval.

    s29: This symbol indicates that some formulations of the associated medicine are legally only able to be prescribed under section 29 of the Medicines Act. You can see which formulations are section 29 by hovering over the s29 symbol. You can access full medication details from the New Zealand Formulary by clicking on the medication name. Each clinician retains full responsibility for ensuring they have complied with all relevant obligations and requirements of section 29 including obtaining informed patient consent prior to prescribing the applicable medicine.